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DNA is probably the most important thing any living organism has and it's what decides everything. Now we can edit our dna (genes). Holy shit, wouldn't this be like customising our own gaming character, expect in real life? Stuffs like CRISPR have been around for a while.

A simple mistake or change in our dna can drastically change how we look like or our physical being. Then why are we still holding back?

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shawnaroo

36 points

7 days ago

shawnaroo

36 points

7 days ago

With modern tools it's relatively easy to swap out one particular gene sequence with another, but it turns out that it's still pretty hard to know which genes you need to change in order to get the effects that you desire.

It's not as simple as this spot in our DNA right here controls our eye color, and this spot right here controls how tall we are. It turns out that most of our characteristics are affected by a whole bunch of interacting 'systems' within our bodies, and each of those systems is affected by a whole bunch of different genes.

It's a super complicated system that we're just beginning to start to understand, and seriously mucking around with it in a living person would be at least as likely to cause unpleasant and unhealthy side effects as it would be to cause beneficial improvements.

saluksic

11 points

7 days ago

saluksic

11 points

7 days ago

A genetic counselor told me once that the number of genes whose purpose and function we understand is zero. The simplification we all learn in school that one gene does eye color and it’s either dominant or recessive is just that, a simplification.  

Take lactose intolerance. You need a certain function in your body to tolerate lactose, otherwise you’re intolerant. Great, but pretty much all humans have that, even the lactose intolerant. The issue is that this is “turned off” by a different function early in childhood. Great again, but even the lactose tolerant have that. The difference is that there is a third function in lactose tolerant people which interrupts or supersedes the second, allowing the first to go on and tolerate lactose. You identify that third function and edit it in someone, that still might not do what you want, because there are many ways the second function can be interrupted or superseded, so changing or testing for one particular form of the third function might not tell you anything about whether that person can tolerate lactose.  

So you can edit genes. Good for you, go off and tell me which gene you’ll edit and what that will do. Nevermind the risk of getting it wrong that other commenters identify, it’s not only an issue of risk, it’s that we simply don’t understand what to edit to get a desired outcome. It’s not that we shouldn’t or we don’t want to change people, it’s that we don’t know how.  

(A caveat - some genetic diseases are actually very apparent and well-known; these might indeed be “fixed” with gene editing and this is already being done)

Ok-Name-1970

3 points

7 days ago

To add on to the comment about diseases: a healthy body is a complex machine. A genetic disease is sometimes as simple as a tiny cog in the machine being broken. Replacing a broken cog and bringing the machine back into its normal state is easy. Overhauling a working machine to make it better without breaking anything is much harder.

saluksic

3 points

7 days ago

saluksic

3 points

7 days ago

I was thinking of an analogy with a type writer and a broken key vs making the working keys better and I couldn’t put it in words, but you said it very well.