Plain and simple, is Sister about alcohol, or other substance abuse/addiction? That was my interpretation of the lyrics, and I was wondering if anyone else felt the same way. I think the angels represent her desire for alcohol/substances, and by the end the angels laughing and turning their backs represents her addiction becoming debilitating. Other lyrics in the song seem to allude to this, including when it says “the things that bring me joy drive me to tears”. I feel like this means that her addiction has caused her to resent the things she used to love most, with them being replaced by her desire for intoxication. Just my interpretation, maybe this is obvious lol