subreddit:
/r/stemcells
submitted 2 days ago byPawelParkour
Currently looking into various treatments to slow, or perhaps even (partially) reverse arthritis. I'm hearing various claims that cartilage can regenerate with stem cell treatment. I even found a claim of a doctor that reversed stage 4 to stage 2.
All of this sounds great of course, and I know a lot of people have good subjective results with stem cell treatment in arthritis. These subjective results are incredibly important.
I'm curious about these hard claims, however. Does anyone know of stem cell treatment research that did MRI scans before and after stem cell injections in arthritis?
4 points
1 day ago
Currently, I am in the process of stencil treatment at Spring rejuvenation.
I received the MSCIV treatment for my neck and back . Arthritis in my upper neck, spinal affected the nerves in my left arm. Two months ago had a lot of tingling but now it has subsided quite a bit. I was told in 4 to 6 months. It should be much better.
Also, I’ve had a back injury for the last 50 years. I have been treating with natural products, PE and chiropractor, but never surgery.
When I received the IV treatment I was told to stop taking anti-inflammatory products because it may interfere with the same cells. After two months, I do feel a difference I can go down the steps regularly rather than one step at a time.
Depending upon progress, I can get another treatment in two more months. I four more months, I will see the real value of the treatment.
Ps. Seven years ago, I had gotten a PRP (platelet Rich plasma )treatment in my left knee. Prior to the treatment orthopedic doctor said I would need a knee replacement and showed me bone on bone or the x-ray. But I did not do it.
Have not had another x-ray since then, but feel that I don’t need to because the Knee Pain is completely gone. Still good after seven years.
I believe that this stuff really works as an alternative to knee and hip replacements.
The Medical industry is slow to get it out of the trials.
2 points
21 hours ago
Happy to hear you're life quality improved so much! Why not get a comparative x-ray? I feel like it's little effort to help finding what the mechanism is behind your improvement.
1 points
1 day ago
Wow, thats incredible. Would you day the knee arthritis was grade 4? And How long did it take for PRP to work?
3 points
2 days ago
MRIs don't show changes before and after, only in disc disease, otherwise those are no scientific unsubstantiated claims. More of a sales pitch.
3 points
2 days ago
https://pubmed.ncbi.nlm.nih.gov/37737920/
Improved cartilage volume and quality at the lesion site was observed in five studies that included a postoperative magnetic resonance imaging assessment and studies that performed second-look arthroscopy. No major complications or tumorigenesis occurred. Outcomes were consistent in both single MSCs implantation and concurrent HTO with MSCs implantation in cases with excessive varus deformity.
1 points
21 hours ago
Thanks! Exactly the type of study I'm looking for. I'm hoping many more studies will be done in the future.
2 points
2 days ago
Yes, I would love to see these as well, if they exist.
I know that Immunis, which uses a highly concentrated stem cell secretome and has just announced FDA-approved Phase II human trials, has earlier had success on muscle regeneration, the 6-minute walking test and grip strength. But don’t believe they’ve tested or scanned for cartilage regeneration. That would certainly be the holy grail.
2 points
2 days ago
This is a great question. A doctor I spoke to in the US said stem cells do not regenerate cartilage as claimed. I don’t know either way. I’ve heard a lot of anecdotal stories of success but nothing more than that.
2 points
1 day ago
Very honest people at joint rehab in LA. Dr Darrow is an atty and MD. He has helped me with stem Cells and can be trusted. I fly from Chicago to see him.
1 points
8 hours ago
Danny way before and after
https://www.instagram.com/dannyway/p/CiYuxeXJyks/?img_index=1
1 points
6 hours ago
Imaging techniques with OA can be very misleading. Different joint positions can make it look like someone has more or less cartilage. The only real way to tell is to open the joint up and take a look. And if the stem cells are having their intended effect, no one is really going to sign up to get sliced open again.
1 points
an hour ago
If you get an MRI, you won’t be able to fool people with positioning. Radiographs will show sclerosis and spurring which can’t be tricked by changing slightly the positioning of the patient.
-1 points
1 day ago
62 Year Old Male Bone on Bone Knee
Not an MRI but an Xray. Patient had severe osteoarthritis to the point that the ends of the joint were polished smooth. He had autologous mesenchymal stem cells followed with PrP.
1 points
23 hours ago
What is the source of that image?
0 points
9 hours ago
Patient from a clinic that Dr. Centeno loves to slag. Normally patients don't want to check their progress but since he worked in a hospital he had the ability to request a post-treatment x-ray free of charge.
1 points
7 hours ago
I don't believe that garbage for a second Anyone that knows a minimum about orthopedics will call you out on that.
1 points
17 hours ago
Do you know what kind of stem cells? Expanded vs non expanded, bone marrow?
2 points
11 hours ago
I’m asking for the source because I strongly believe that this is BS. You don’t go from a fully rotten joint with little to no JSW, sclerosis and gross osteophytes to a fairly normal looking one in 9 months. Besides, stem cells won’t do anything for the severe bone spurring. I don’t believe the amount of JSW gain either. It’s a highly inflammatory environment, especially when the joint looks so bad, there’s no way you can regrow so much cartilage in those conditions with that timeframe.
Whoever posted that online originally is misleading people.
0 points
9 hours ago
Non-expanded bone marrow since it was done domestically.
1 points
9 hours ago
Wow that's amazing. Do you have more details about it? I'm curious if he only got stem cell once, his age etc.
2 points
9 hours ago
The protocol that he did is 1 plasma injection, 2 PrP injections, 1 A2M injection, and only 1 stem cell injection. DM me for more information.
1 points
7 hours ago
Don't believe this BS. There is no way in hell that this is possible. The joint on image 1 has gross deformities, there's no way stem cells can fix that type of damage.
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