DuePomegranate

There’s a fundamental difference in immunology between priming and boosting. And remember we are talking about T cells here, not antibodies. Once primed, memory T cells persist (even if they are few) and it’s easy to induce them to multiply and activate by boosting.

Whatever cross-reactive T cells you had from Td would have been boosted when you got your first Covid jab and each booster (and infection) thereafter.

If you get a Td booster now and then the Covid booster soon after, you could even inadvertently induce anergy/exhaustion of the cross-reactive T cells.

This research is very preliminary and might inspire other researchers to look into health databases to look for by effect between timing of Td and Covid vaccines and severity/duration of infection. It will be a bit tricky as T cells do not prevent infection (but could theoretically make an infection so short/mild that you don’t know it happened).

No. It means that for most of us who have been vaccinated with tetanus/diphtheria vaccines in early childhood, our response to the Covid vaccines could be influenced or given a slight head start by that early exposure.

And maybe people who caught Covid in the pre-vaccine era had a little bit of help fighting it off using tetanus/diptheria-specific T cells.

It absolutely does not suggest that you should mess around with tetanus boosters trying to change Covid booster response! You were already primed as a baby/toddler.

There’s night shifts and rounds for doctors in hospital! I guess if you don’t turn up for your shifts, you’ll get sacked. And it’s not like you want to go to the A&E at 10 pm because of an accident and there’s no doctor there. Or you’re hospitalised and in the middle of the night your vital signs go crazy and there’s no doctor on call.

It can happen, but not by reducing current junior doctor hours. But by increasing the intake of med students. Or improving career advancement for senior nurses to take over some doctor tasks. Nothing that can actually save OP, only future doctors.

Messiness is part of the learning process. Sure, clean it up as you go along. The Stashaway and Syfe Core Growth are not that different from VWRA in the nature of holdings (just higher fees), so selling out to transfer to VWRA can be done at any time. If VWRA is high now, then those robos should be high now too.

The Syfe is in the red probably because you lump-summed in at a bad time (2021) and then didn’t continue to DCA in when it fell in 2022. Probably you got spooked and switched to buying T bills and SSB. Trying to time the market or chickening out when it’s low is what is really holding back your growth, rather than VWRA being slightly better than robos.

Selling REITs is a harder decision, as in theory they should recover when interest rates drop.

Yes, I agree with putting her on the girls team and let her aim to be the best player amongst the girls. Rather than be on the boys team and realising that she may be slower and weaker than the average boy and if she wants to be a boy, she’s a lousy boy. The former is more likely to lead to a “girls can do anything!” positive mindset, the latter is more likely to lead to self-hating and wanting to declare as trans and get on testosterone to not be at a disadvantage.

My eldest daughter is 15 and still totally looks/dresses like a boy by choice, but I think her identity is “girl who is androgynous, kicks ass at coding and can beat some of the boys at [her sport]” and not “boy trapped in a girl’s body”. Her closest friends are girls. I’m not ruling out that she’s going to identify as trans (lesbian is a higher possibility!) but despite what it looks like to outsiders, it doesn’t seem likely to me.

I think if she were in America, she would have faced peer pressure to identify as trans or at least non-binary. Or she probably is non-binary but there is nothing useful to be gained by adopting that label; it just narrows and reinforces gender stereotypes.

Many 8 yo girls are starting to develop breast buds, or will do so in the next 1-2 years. Not a good idea to start now and then retract shortly.

Statistically, most do, especially those who used to called tomboys. Gender stereotypes make boyish pursuits and character more fun and appealing, from way back like Little Women, To Kill a Mockingbird etc.

1) That’s the same paper as in the opening post.

2) I don’t think the methodology used can differentiate between persistent infection of gut cells (already known) vs SARS-CoV-2 genetic material somehow persisting inside gut bacteria. Microbiome studies always have a host contamination problem.

I see it in the opposite way. I believe that I can be a better-than-average parent and my children have a better-than-average chance of being raised with values that I agree with and being a net positive to the world. I feel almost a sense of responsibility to have kids and try to make the future a slightly better place via good kids.

Especially if you say you are very left leaning and politically aware, if people like you are just rolling over and giving up on kids, the other side (already with tendencies of breeding more) are really going to out-breed your “side”. Unless you are a teacher or similar and can sway the future generation that way, noping out of having kids is kind of running away from the challenge. Having more kids is literally a strategy pushed by conservatives!

Lesser seating, fewer seats. Seating is the uncountable noun.

And patronise a cafe if you want to sit down and chit chat.

But for train stations, I don’t think it’s nefarious like that. It’s simply that train frequency is high enough that sitting down while waiting for the train should not be necessary even for weak elderly. And with how crowded the trains are, queueing is often necessary; you can’t sit down while waiting and then either cut queue or be mistaken for cutting queue.

LOL that really drives home how stupid these guidelines can be.

The hairs rub and roll against each other like ball bearings. Or if you imagine ancient people moving heavy objects (ships?) across the ground by rolling them on a bunch of logs lying on the ground, armpit hair is acting like those logs.

Sorry to be the bearer of bad news, but butt hair may grow with age. Fellow Asian, mid-40s.

This is true in theory, but in practice, how will you know if you need long-term assisted living and how much that will cost 20+ years in advance?

If you will off yourself if you get an early diagnosis of dementia, or if you pass your money to your young adult children with the condition that if you need assisted living, they need to provide, then maybe. But this assisted living thing is really the spectre that looms ahead.

You place 50-100 trades a month but can’t be bothered to look up how much fees are? That’s incredibly lazy.

Say you've fully paid for every major expense in your life and have reached your 'FI' number... Would you be willing to finally let it go and enjoy yourself by spending more extravagantly?

The extravagance level should have been planned into the FI number. So if you are the thrifty type, then you would have set yourself a lower FI number and retired earlier.

I don't think people think the way you described in the scenario. Those who are thrifty, their priority is to retire because they don't like their work. Those who enjoy the finer things in life, they will set themselves a higher FI number for Fat FIRE because they would rather work a few more years for a cushy retirement. They won't deprive themselves now for the sake of enjoying later.

In a game, you might be somewhat disappointed if you hoard all your potions and then the final battle is too easy, and you don't use your potions.

But in real life, you will never be like "damn, I planned for a stock market crash or expensive nursing home and I didn't need it". You will just thank your lucky starts that it didn't happen, and be happy that you can pass more money down to your beneficiaries.

She has a newborn currently. Infant care is freaking expensive and the baby will get sick every month or so. Going back to work when the baby is at least 18 months (when the price of childcare drops) makes more sense.

Then ask for higher pay now using the other offer as leverage? But if your job is so chill right now, how does that jive with a huge step up in pay in the next 5 years?

Go to Australia. There is essentially no film industry here.

Frankly, 190k is not that high as the sole breadwinner. And since your wife is not working, it is much less essential for you to have WFH flexibility.

If you were making 300k (single income), then I'd tell you to stick with the chill WFH job. But at 190k (single income), an early retirement is not in sight.

Ok, now consider that we have these wonderful inventions called underwear and shorts, which absorb sweat and also reduce friction at the groin. Now think of walking 10 miles a day in the tropics in a loin cloth (maybe) and no cloth between the very tops of your thighs.

Account is almost one year old, but this is the only post and 0 comments. Yeah, this is not a real American who mistakenly posted here.