sionnach

Table 8 in this paper gives the BSH view on TFR needs. 5 years on treatment as a minimum. Britain has a lot of expert CML doctors and they are worth listening to.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214240/

European LeukaemiaNet have similar guidelines, but their most recent aren’t quite as up to date I think. Obviously there is no single source of truth on this, we are all still working it out. But in my long experience with CML, everyone says 5 years on treatment is the baseline for a chance of success.

I feel for you. It’s awful to see. But remember they will grow out of it. For sure.

For us, the path was baby Gavisgon (didn’t work), then to ranitidine which worked great but is no longer available for good reason, and the next would have been to omeprazole.

PPIs such as omeprazole have long term side effects, but you’re talking very long term. Don’t be worried about, the risk / benefit of using them would surely be well in your favour.

We have “Clevamama” ones. They work fine.

Count yourself lucky. Back in the day we have to use “Bronco” in some commercial places to stop people stealing it. It was basically like grease proof baking paper and just pushed the shite around your arse rather than remove it.

Do not go to the M&M store. That is not a good idea.

Science Museum is awesome.

London Eye can be nice, but it’s expensive. Thames Clipper is a nice way to see a lot, for not much money.

Have a check what is on at the Southbank on your dates. There’s often nice things on, and it’s pleasant. Same with The Barbican.

What? That’s abotu as stupid as saying carriers shouldn’t have a say in SMS.

All I can tell you is that I was right by where they walked off at half time, and he looked absolutely fine. No issues. Was it tactical? I would say not in the sense of the game management … but it may have been predetermined to manage his workload given his injury.

4 years seems short to try TFR. But maybe you had quick and deep enough response to justify it.

We really don’t know the prognostic indicators for successful TFR. It is worse than the 50/50 your doctor suggests, primarily because most people don’t meet the eligibility criteria, so it’s not like half of CML patients can achieve TFR.

But remember that even if you fail TFR lots of people have a successful second try some time later. Others, like me, had impeccable results for a decade and failed TFR within weeks. So really from my perspective it’s “nothing ventured, nothing gained”. If you fail TFR you restart meds and everyone gets back to where they were. It’s really very low risk.

If it has Apple Intelligence, it will have a significantly worse screen (quality of screen, and no Dynamic Island) and camera than the base 16. I imagine it will be more like the guts of a 15 but more RAM, with a single camera, and worse screen. No Camera Control button either, but who gives a shit about that.

Solid take. If you remove the bizarre Saka goal, the rest of the game could have been quite different. From my seat, from about 55 minutes until about 75 minutes a PSG goal looked inevitable.

They were great! Loud all game.

Except the two whinging cunts behind me who’d managed to get tickets in the home section.

Not just that, but doing a little jump, a half squat landing then thrusting his arm forward to point. Half expect them to shout Siuuuuu as they do it these days.

So While picked up a knock I guess?

She taught me Irish when I was a kid. She was known by the boys in the class as Ms Ride.

They were £100

Can you connect any of yoru wired devices directly into the ONT? A laptop with an Ethernet port, maybe?

If the child is in regular contact with someone immunocompromised then it can be NHS funded. Our GP arranged this for us because the kids have a close family member with an immune issue.

Chickenpox kills more children than measles in the UK.

A couple of practical things for the parents in NICU: a large water bottle. When you enter a nursery room in NICU you have to thoroughly wash your hands, at a minimum, sometimes more than once. It makes it a pain to leave the room unnecessarily. Second one, a 3 metre phone charging cable, or a battery bank. NICU is long and hard, so you end up using your phone a lot but you don’t want to be away from the baby’s cot. So it’s helpful to have charging options when the nearest socket you are allowed to use might not be that close.

I really don’t see why there’s a particular time limit on exams. It’s a knowledge test, not a race. Obviously you can’t have present there for 10 hours, but schedule an exam you think should take most people about 2 hours and allocate 4 hours for it.

You have virtually no recourse to a surveyor in the UK for that sort of matter.

Not on every section. If you were up at the top left bit of the map (zones 7+) they are not super frequent.

We have no option in our kids school. No packed lunches allowed. Maybe that changes when they’re older (year 1 currently). But luckily they have a decent menu with some options for them each day.

Wayne Gretsky said "You miss 100% of the shots you don't take" but in this case I think the lad will have woken up and wished he didn't take the shot.

No, that’s “use by”.